Anushka DongreRochester, Minnesota, is best known as the home of the world-renowned Mayo Clinic, but it also offers a welcoming atmosphere, scenic parks, and a variety of restaurants and entertainment options. Whether you’re visiting for medical treatment, work, or leisure, these top-rated Airbnb Stays in Rochester provide comfort, convenience, and a home-away-from-home experience.
10 Best Airbnb stays in Rochester, Minnesota to book in 2025
1. This modern retreat offers stylish comfort in a central location
Listing name: Modern Serenity House 4bd/2 ba
Listing type: Entire home
Max. no. of guests: 7
Nearby attractions: Mayo Clinic, downtown Rochester
A beautifully designed home blends contemporary style with cozy warmth, making it the perfect getaway for families or small groups. The fully stocked kitchen allows for easy meal preparation, while the inviting living space is ideal for relaxing after a long day. Each of the four bedrooms features plush bedding, ensuring a restful night’s sleep. Conveniently located near local attractions and amenities, this home is an excellent base for exploring everything Rochester has to offer.
2. This spacious home offers comfort and convenience near Mayo Clinic
Listing name: New! MN Comforts The Heart 4Bd/2Bth, 12min to Mayo
Listing type: Entire home
Max. no. of guests: 10
Nearby attractions: Mayo Clinic
Perfect for both short and long stays, this thoughtfully designed airbnb in Rochester provides a peaceful retreat with a blend of modern and traditional décor. With two spacious living areas, a fireplace, and a work station, it caters to families, business travelers, and those visiting Mayo Clinic. The split-level layout includes two bedrooms on the main floor for easy access, and a fenced backyard provides a private outdoor space for relaxation. Located near shops and restaurants, this home ensures a comfortable and convenient stay.
3. This spacious home is ideal for large groups and Mayo Clinic visitors
Listing name: Walk to Mayo St Mary – 1419N – Cozy 5Bed/6Bath House
Listing type: Entire home
Max. no. of guests: 10
Nearby attractions: Mayo Clinic St. Mary’s Hospital, downtown Rochester
Situated in one of Rochester’s most secure and elite neighborhoods, this five-bedroom home offers unparalleled convenience for those visiting Mayo Clinic. With six bathrooms, two full-size kitchens, and multiple lounges, it comfortably accommodates large groups or extended family stays. Guests can unwind in the outdoor space featuring brick patios, a fire pit, and a lush lawn. Inside, the pool table and high-speed WiFi add to the comfort and entertainment options.
4. This lakeside retreat offers tranquility just minutes from downtown
Listing name: Peaceful Stay by Silver Lake, Fireplace, KingBed
Listing type: Entire home
Max. no. of guests: 9
Nearby attractions: Silver Lake, Mayo Clinic
Nestled in a peaceful neighborhood near Silver Lake, this home offers a relaxing escape while remaining close to downtown Rochester. The spacious layout includes three bedrooms on the main floor, a modern kitchen, and two large family rooms. Guests will appreciate the attached garage, on-site washer and dryer, and high-speed internet. The fenced yard provides privacy and serenity, while nearby walking paths and picnic areas make it easy to enjoy the outdoors.
5. This boutique-style home combines charm and convenience
Listing name: Entire Boutique Home Kutzky Park ★ Walk to Mayo ★
Listing type: Entire home
Max. no. of guests: 6
Nearby attractions: Kutzky Park, Mayo Clinic
Located in the desirable Kutzky Park neighborhood, this expertly designed home is perfect for those looking to stay near Mayo Clinic while enjoying a charming residential setting. The thoughtfully furnished interior includes three relaxing bedrooms, a fully equipped kitchen, and a cozy reading nook. Guests can unwind with a cup of coffee at the coffee bar, catch up on work with high-speed WiFi, or enjoy a Netflix marathon. With local dining and shopping within walking distance, this home offers both comfort and convenience.
6. This stylish apartment offers river views and modern luxury
Listing name: Peaceful 2Bed/2Bath Apartment w/Balcony near Mayo
Listing type: Entire rental unit
Max. no. of guests: 4
Nearby attractions: Zumbro River, Mayo Clinic, downtown Rochester
Tucked away along the scenic Zumbro River, this upscale Airbnb in Rochester offers a peaceful retreat just minutes from Mayo Clinic and downtown Rochester. Featuring an open-concept layout with high ceilings and contemporary finishes, this space blends elegance and comfort. Guests can enjoy the fully equipped kitchen, premium bedding, and a private balcony with stunning river views. With fast Wi-Fi, smart TVs, and in-unit laundry, this pet-friendly home ensures a seamless stay for travelers seeking relaxation and convenience.
7. This modern home offers a serene escape with top amenities
Listing name: Modern Gem. Close to Mayo. Office/Fast Internet
Listing type: Entire home
Max. no. of guests: 8
Nearby attractions: Silver Lake, Mayo Clinic
Perfect for professionals, families, or long-term guests, this mid-century modern home combines style and comfort. The thoughtfully designed space includes four cozy bedrooms, a dedicated office, and a fully equipped kitchen. High-speed Wi-Fi, streaming services, and a fireplace add to the home’s appeal, while the spacious backyard provides a relaxing outdoor area. With easy access to Mayo Clinic, parks, and shopping, this home offers both convenience and tranquility.
8. This spacious duplex offers privacy and modern comfort
Listing name: The BEST Stay in Town: See Pics+Reviews to Believe
Listing type: Entire home (one side of a duplex)
Max. no. of guests: 6
Nearby attractions: Mayo Clinic, Target
A stylish and modern Airbnb in Rochester provides a private, one-level living experience perfect for families, business travelers, or extended stays. Featuring two bedrooms, a spacious living area with a fireplace, and a fully equipped kitchen, this home offers all the comforts you need. Guests will appreciate the high-speed Wi-Fi, Smart TV with Netflix, and private deck. With no stairs and a quiet neighborhood setting, it’s an excellent choice for elderly guests or those looking for an accessible stay.
9. This luxurious home provides a perfect mix of entertainment and relaxation
Listing name: The Sierra! Close to Mayo Clinic
Listing type: Entire home
Max. no. of guests: 10
Nearby attractions: Mayo Clinic, downtown Rochester, parks
A beautifully designed home offers a blend of luxury and family-friendly amenities. Featuring a spacious family room with a fireplace, a fully equipped kitchen with quartz countertops, and a stunning vaulted primary suite, this property ensures a high-end stay. Guests can enjoy entertainment options like a foosball table, darts, and Smart TVs. A charming front porch and rear patio provide additional spaces to unwind. Pet-friendly accommodations make it an excellent choice for travelers with dogs.
10. This cozy home offers an unbeatable location near St. Mary’s Hospital
Listing name: FLasH Sale! Restful Heart House @ St. Marys
Listing type: Entire home
Max. no. of guests: 8
Nearby attractions: St. Mary’s Hospital, Mayo Clinic, Pill Hill neighborhood
Located in the prestigious Pill Hill neighborhood, this charming home is perfect for those visiting Mayo Clinic. Just steps from St. Mary’s Hospital, guests can easily access the free Mayo Shuttle for added convenience. The home features four queen beds, a play area for kids, a private backyard, and garage parking. Hardwood floors throughout and a well-stocked kitchen create a warm and inviting atmosphere, making it an excellent choice for both short and extended stays.
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No matter the purpose of your visit, these Airbnbs provide a comfortable and convenient stay in Rochester. Whether you’re here for medical appointments, business, or leisure, you’ll find the perfect place to call home during your stay.
